Training in molecular medicine is intended to combine rigorous didactic training in the basic biomedical sciences with exposure to concepts and knowledge underlying the molecular basis of disease. Trainees should have training in the core concepts of molecular biology, cell biology, biochemistry, genetics and related biomedical sciences. In addition, trainees in molecular medicine should have specialized required courses such as pathophysiology and molecular pathogenesis, and program activities, such as seminar series or journal clubs that would provide students with a better understanding of disease mechanisms. Other features that would enhance training in molecular medicine could include dual mentors in basic and clinical science, and exposure to the concepts of medicine through participation in grand rounds or autopsy internships. Training faculty should be broadly drawn from multiple departments and disciplines and thesis research topics should reflect a broad range of interdisciplinary opportunities in the basic biomedical sciences.